Tesamorelin

Tesamorelin

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog. It was based on the 44 amino acids sequence of GHRH and contains a trans-3 hexenoic group to protect it from enzymatic degradation. These modifications allow it to be more stable and have a longer half-life.

Just like Sermorelin, Ipamorelin or GHRP-2, Tesamorelin is considered a growth hormone secretagogue (GHS) which stimulates the secretion of GH and increases the level of insulin-like growth factor (IGF-1). The importance of IGF-1 is it tends to be lower in patients with obesity, diabetes and especially in those with lipodystrophy.

References:

Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.

CAD $70.00 – CAD $125.00

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What Is Tesamorelin?

Tesamorelin is a synthetic peptide used in medicine for a specific purpose. It is classified as a growth hormone-releasing hormone (GHRH) analog and is primarily used to stimulate the production and release of growth hormone (GH) from the pituitary gland. This hormone is crucial in various physiological processes, including growth, metabolism, and tissue repair.

This peptide is often used with HIV-associated lipodystrophy. According to some animal studies, it helps reduce excess abdominal fat, improving body composition and potentially enhancing insulin sensitivity.

Tesamorelin Structure

Sequence (Single Letter): Unk-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu
Molecular Formula: C223H370N72O69S
Molecular Weight: 5195.908 g/mol
PubChem CID: 44147413
CAS Number: 901758-09-6

Tesamorelin and Lypodystrophy

Tesamorelin is a synthetic growth hormone-releasing factor that has shown promise in the treatment of lipodystrophy, particularly with HIV-associated lipodystrophy. Lipodystrophy refers to changes in body fat distribution and metabolism that can occur as a side effect of antiretroviral therapy for HIV.

Several animal studies have demonstrated the efficacy of tesamorelin in reducing central fat accumulation and improving visceral adiposity with HIV-associated lipodystrophy. Clinical trials have shown that tesamorelin injections can significantly decrease visceral abdominal fat.

Furthermore, tesamorelin has been found to have minimal effects on CYP3A, an enzyme involved in drug metabolism. This suggests that tesamorelin may not interfere with or be affected by medications metabolized by CYP3A.

The U.S. Food and Drug Administration (FDA) has approved tesamorelin for the treatment of lipodystrophy in patients with HIV. This approval was based on the positive results from clinical trials showcasing the effectiveness of tesamorelin in reducing visceral fat and improving lipid profiles.

Tesamorelin Investigated in Cardiac Disease

While tesamorelin has primarily been studied in treating lipodystrophy, there are also investigations into its potential effects on cardiac disease. However, it is important to note that long-term cardiovascular benefits have not been extensively studied.

One animal study found that lower visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) density, which can be improved by tesamorelin, were associated with lower levels of adiponectin (a protein involved in regulating glucose and fatty acid metabolism) and increased cardiovascular disease risk.

Growth Hormone Deficiency and HIV

Growth hormone deficiency (GHD) can be a common complication in individuals with HIV infection. HIV-associated lipodystrophy often includes GHD as one of its components.

Based on the animal studies, GHRT can help increase lean body mass, decrease fat mass, and improve lipid profiles. It has also been associated with improvements in bone mineral density and quality of life.

However, it’s important to note that the use of GHRT in HIV should be carefully evaluated and monitored, as there may be potential interactions with antiretroviral medications and other comorbidities.

Tesamorelin for Peripheral Nerve Damage

Tesamorelin has been investigated for its potential use in peripheral nerve damage. Several studies and clinical trials on animals have assessed its efficacy in enhancing axonal regeneration and improving functional outcomes following peripheral nerve injuries.

These studies suggest that GH-based therapies, such as tesamorelin, hold promise in the treatment of peripheral nerve injuries due to their multi-modal mechanism of action.

Tesamorelin Investigated in Dementia

Exciting new evidence has emerged regarding the potential benefits of GHRH analogues, including tesamorelin, in enhancing cognition in the early stages of dementia. A groundbreaking study conducted at the University of Washington School of Medicine shed light on the positive influence of tesamorelin and similar analogues on dementia by modulating specific brain chemicals.

In this comprehensive twenty-week-long study, researchers employed a rigorous methodology with randomized, double-blind, placebo-controlled design. The results pointed towards the intriguing role of tesamorelin in increasing levels of gamma-aminobutyric acid (GABA) while simultaneously lowering (MI) myo-inositol levels in the brain.

Please note that all the articles and product information provided on this website are intended for informational and educational purposes only.

The products offered on this platform are specifically designed for in-vitro studies, meaning they are conducted outside the body.

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